Probiotics and biotechnology

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Probiotics and biotechnology

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This article has been cited by other articles in PMC. Probiotics have become of interest to researchers in recent times. Time has come to shift the paradigm of treatment from specific bacteria elimination to altering bacterial ecology by probiotics.

The development of resistance to a range of antibiotics by some important pathogens has raised the possibility of a return to the pre-antibiotic dark ages. Here, probiotics provide an effective alternative way, which is economical and natural to combat periodontal disease. Thus, a mere change in diet by including probiotic foods may halt, retard, or even significantly delay the pathogenesis of periodontal diseases, promoting a healthy lifestyle to fight periodontal infections.

Altering the building blocks of life is a wise and precise way to correct flaws.


There have been major shifts in treatment paradigm from nonspecific to specific approach. Now treatment options propose altering ecology Probiotics and biotechnology niches, in order to modify pathological plaque to a Probiotics and biotechnology of commensalisms.

Probiotics and biotechnology

Probiotics are live microorganisms administered in adequate amounts with beneficial health effects on the host. Probiotics nano soldiers refer to genera of organisms, which play a crucial role in halting, altering, or delaying periodontal diseases.

It poses a great potential in arena of periodontics in terms of plaque modification, halitosis management, altering anerobic bacteria colonization, improvement of pocket depth, and clinical attachment loss. Probiotics are broadly categorised in two genus Lactobaccilus and Bifidobacterium.

While other microorganisms also classified into this group includes yeast and moulds e. Probiotics have evolved for more than 10 decade back to present day.

Table 1 Open in a separate window Proposed mechanics of probotics: Various mechanisms have been proposed for probiotic actions. Probiotics have been documented to modulate host immunity both systemically and locally. These were earlier thought to act on gastrointestinal tract mucosa only. Probiotics stimulate dendritic cells antigen presenting cells resulting in expression of Th1 T-helper cell 1 or Th2 T-helper cell 2 response, which modulates immunity.

Intracellular pathogens are phagocytosed by Th1 response, while extracellular pathogens are taken care by Th2 response. Probiotics can mimic response similar to a pathogen but without periodontal destruction. Other proposed mechanisms include Glycoprotein — carbohydrate cell surface interaction mediate by inter species interactions.

Lactobacillus rhamnosus, and Lactobacillus paracasei have strong binding activity to primary pellicle. Lactobacillus rhamnosus, Lactobacillus casei shirota, Lactobacillus casei ATCC prevent adherence of bacteria to salivary pellicle by altering its composition.

Aggregation alteration is another important proposed mechanics as Hetrofermentative Lactobacillus is the strongest inhibitor of Aggregatibacter actinomycetem comitans, Porphyromonas gingivalis and Prevotella intermedia. Lactobacillus rhamnosus co-aggregates with Fusobacterium nucleatum.

Weissella cibaria isolates generated a substantial quantity of hydrogen peroxide, which was sufficient to inhibit the proliferation of Fusobacterium nucleatum.

Probiotics stimulate apoptosis of tumor cells through end product formation. Decrease in pro inflammatory cytokines by probiotics ingestion is another mode of action as seen in gingival crevicular fluid GCF of patient on chewing gum containing Lactobacillus reutri.

Streptococcus oralis and Streptococcus uberis have reported to inhibit the growth of pathogens both in the laboratory and animal models. They are indicators of healthy periodontium. When these bacteria are absent from sites in the periodontal tissues, those sites become more prone to periodontal disease.

Lactobacillus reuteri was evaluated by Krasse et al. A parallel, double-blind, randomized, placebo-controlled study with 59 patients having moderate-to-severe gingivitis were taken up. After 2 weeks, the clinical parameters were improved in group consuming probiotics chewing gum.

In a one-way crossover, open-label placebo-controlled study Kang et al. Subjects rinsed in morning twice with 15 ml rinse containing probiotics strain.Ganeden is an international probiotic ingredient manufacturer best known for GanedenBC30 and Bonicel - check out our website for more info.

Mystical Biotech Private Ltd is a leading Neutraceuticals manufacturing company in India. An ISO certified company, having its manufacturing unit near Bangalore, Karnataka, is designed to meet international standards of product’s quality and environment protection. Probiotics and Biotechnology Essay.

Probiotics and Biotechnology. Bacterias are present in the intestine of every 1 - Probiotics and Biotechnology Essay introduction. Some of these are harmful while others are good for the wellness of host. Probiotics and Kidney Health The application of probiotics to kidney health is an emerging area of medicine that has only recently come into the p ublic eye in America.

Experts have debated how to define probiotics. Probiotics are living bacteria or other microorganisms which may be beneficial to the health of humans or animals when consumed. Beneficial bacteria include Lactobacillus and Bifidobacterium spp.

and other lactic acid bacteria. Much has been written in both the medical literature and lay press about their potential benefits, some of it well validated by randomized controlled trials but other.

World Probiotics is an unprecedented event planned for specialists to empower the spread and use of research revelations on Probiotics & Prebiotics, Food science, Nutrition and Microbiology, Immunology, Biochemistry, Skin Microbiota, Gut Microbiome, Digestive Health, Industrial Production and Dairy Technology, Human Microbiome, Diet and Health.

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